PURINE AND PYRIMIDINE ANTAGONISM IN A PYRIMIDINE-DEFICIENT MUTANT OF NEUROSPORA
نویسندگان
چکیده
منابع مشابه
Purine and pyrimidine antagonism in a pyrimidine-deficient mutant of Neurospora.
Inhibitions of the growth of organisms by closely related structural analogues of several water-soluble vitamins are well known. Similar types of antagonism in the case of purine and pyrimidine metabolites are those between the purine bases, adenine and guanine, and benzimidazole (1) and between barbituric acid and uracil in the growth of Staphylococcus aureus (2). In such cases the antagonism ...
متن کاملCharacterization of a mutant mouse lymphoma cell with deficient transport of purine and pyrimidine nucleosides.
A clone (AE1) of cells resistant to adenosine cytotoxicity was isolated from a mutagenized population of mouse T-lymphoma (S49) cells. These adenosine-resistant cells cannot transport adenosine or any other purine or pyrimidine nucleoside tested, but their transport of purine bases is intact. The AE1 cells also have an impaired ability to salvage thymidine. Kinetic analyses of the uptake of pur...
متن کاملPurine and pyrimidine metabolism.
The pathways of purine biosynthesis and degradation have been elucidated during the last 30 years; the regulation of the mechanisms involved is not yet fully understood, particularly with respect to quantitative aspects. Research into inborn errors of purine metabolism has provided valuable insights into purine synthesis and salvage pathways. Nutrition experiments using purine-free formula diet...
متن کاملProtonated pyrimidine-purine-purine triplex
We have studied a protonated pyrimidine-purine-purine (Py-Pu-Pu) triplex, which is formed between the d(C)nd(G)n duplex and the d(AG)m oligonucleotide as the third strand and carries the CG*A+ protonated base-triads. We have observed such an intermolecular complex between a plasmid carrying the d(C)18 d(G)18 insert and the d(AG)5 oligonucleotide without bivalent cations in 200 mM of Na+ at pH4....
متن کاملReview Purine and pyrimidine receptors
Adenosine 5’-triphosphate (ATP), in addition to its intracellular roles, acts as an extracellular signallingmolecule via a rich array of receptors, which have been cloned and characterised. P1 receptors are selective for adenosine, a breakdown product of ATP, produced after degradation by ectonucleotidases. Four subtypes have been identified, A1, A2A, A2B and A3 receptors. P2 receptors are acti...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1948
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)57126-x